Fig. 9: (a)A pile up of the main highly conserved sequences of the DPPIVs and related proteins (MacVector Clustal analysis). The numbers in parentheses indicate distance between the end of one and the beginning of the next sequence. The highly conserved residues are in red. The catalytic triad is shown in underlined red bold, the conserved glutamic acids are in green except for the QEE of the DPP8 related proteins (Q in blue). Note the substitution of Gly for Ser in CG9059 (black G).The His residue reportedly necessary for dimer fomation is indicated under (dimer) in red bold (Chen et al . 2004) and the residues that align with the required Tyr (Tyr547 in human DPPIV(Bjelke et al . 2004; Gorrell, 2005)) and the highly conserved Arg125 (Gorrell, 2005) are shown in square brackets.