| Compound |
R |
mp (°C) |
ID50 (nmol)a |
| 1 |
H AIO |
132-134 |
NAb |
| 2 |
2-Br AIO |
129-130 |
NAb |
| 3 |
2-Cl AIO |
118-120 |
NAb |
| 4 |
2-Me AIO |
oil |
NAb |
| 5 |
2-Et AIO |
61-63 |
84.4(71.4-99.8) |
| 6 |
2-i-Pr AIO |
89-91 |
NAb |
| 7 |
4-Cl AIO |
163-165 |
NAb |
| 8 |
4-I AIO |
144-145 |
NAb |
| 9 |
4-CF3 AIO |
133-134 |
NAb |
| 10 |
4-Et AIO |
120-121 |
NAb |
| 11 |
4-EtO AIO |
156-158 |
NAb |
| 12 |
2-Me,3-I AIO |
105-106 |
NAb |
| 13 |
2-Cl,4-Br AIO |
135-136 |
NAb |
| 14 |
2,4-(MeO)2 AIO |
113-115 |
106.0(71.2-435.1) |
| 15 |
2-MeO,5-Cl AIO |
135-136 |
NAb |
| 16 |
2-MeO,5-Me AIO |
85-86 |
28.9(21.0-36.4) |
| 17 |
2,6-Me2 AIO |
oil |
NAb |
| 18 |
2-Me,6-Et AIO |
102-104 |
5.1(1.2-13.8) |
| 19 |
2-Me,6-i-Pr AIO |
oil |
NAb |
| 20 |
2-Et,6-i-Pr AIO |
172-174 |
NAb |
| 21 |
2,6-Et2 AIO |
103-105 |
64.0(55.0-74.4) |
| 22 |
2,6-(i-Pr)2 AIO |
169-170 |
NAb |
| 23 |
3-NO2,4-Cl AIO |
154-156 |
70.9(57.1-91.5) |
| 24 |
3-CF3,4-Cl AIO |
167-168 |
NAb |
| 25 |
2-Me AII |
144-145 |
NAb |
| 26 |
2-Et AII |
103-104 |
NAb |
| 27 |
2,6-Me2 AII |
159-160 |
NAb |
| 28 |
2-Me,6-Et AII |
149-150 |
NAb |
| 29 |
2-Et,6-i-Pr AII |
200-201 |
NAb |
| 30 |
2,6-Et2 AII |
168-169 |
NAb |
| 31 |
2,6-(i-Pr)2 AII |
234-235 |
NAb |
| 32 |
2,4,6-Me3 AII |
174-175 |
NAb |
| 33 |
H AIT |
174-176 |
NAb |
| 34 |
2-Et AIT |
59-61 |
NAb |
| 35 |
2,4-Me2 AIT |
106-108 |
NAb |
| 36 |
2,4,6-Me3 AIT |
99-101 |
NAb |
| 37 |
2,6-Me2 AIT |
169-171 |
82.4(69.4-97.7) |
| 38 |
2-Me,6-Et AIT |
oil |
31.3(10.8-48.3) |
| 39 |
2,6-Et2 AIT |
72-74 |
19.5(16.0-23.8) |
| 40 |
2-Et,6-i-Pr AIT |
138-140 |
NAb |
| 41 |
2-Me SBT |
oil |
9.3(4.5-13.6) |
| 42 |
3-F SBT |
oil |
NAb |
| 43 |
3-Me SBT |
oil |
25.8(14.1-36.6) |
| 44 |
4-Me SBT |
oil |
NAb |
| 45 |
2-Me STO |
oil |
47.9(36.6-60.9) |
| 46 |
3-Me STO |
oil |
NAb |
| 47 |
4-Me STO |
oil |
NAb |
| 48 |
2-Me SBO |
118-120 |
NAb |
| 49 |
2-Cl,4-F SBO |
99-100 |
NAb |
| 50 |
3-Cl,4-F SBO |
90-92 |
NAb |
| 51 |
CBP |
154-155 |
NAb |
| 52 |
CDM |
oil |
NAb |
| 53 |
DIP |
oil |
NAb |
| 54 |
MTO |
oil |
40.4(13.1-252.1) |
| 55 |
NIO |
110-111 |
NAb |
| 56 |
ODA |
oil |
NAb |
| 57 |
ODO |
172-173 |
NAb |
| 58 |
PEO |
123-124 |
3.5(2.3-5.0) |
| 59 |
PIT |
210-211 |
57.1(48.4-67.4) |
|