Figure 1. Overview of metamorphosis of the optic lobes of Manduca sexta. Schematic diagrams based on our sectioned material and on descriptions given in Nordlander and Edwards (1968). A. Overview of larval brain showing outer optic anlagen highlighted in blue and inner optic anlagen in red. The anlagen are shown in their entirety as they would be seen in wholemount rather than as they would appear in a single section. B. Representative section through a pupal brain showing the outer optic anlagen in blue and the inner optic anlagen in red. C. Top view of the adult brain, showing the distinct lamina, medulla, and lobula of the mature optic lobe. The lamina and medulla are outlined in blue to indicate their origin in the outer optic anlagen. The anterior and posterior portions of the lobula are outlined in red to reflect their origin in the inner optic anlagen. Abbreviations: AC, antennal center of the larval and pupal brain; AL, antennal lobe of the adult brain; aLO, anterior portion of the lobula; CE, compound eye; IOA, inner optic anlagen; LA, lamina; MB, neuropils associated with the mushroom bodies; ME, medulla; OOA, outer optic anlagen; pLO, posterior portion of the lobula; TC, tritocerebrum. Scale bar = 100 µm.