and the two JH binding modes in the hvUSP and dmUSP agonist homology models. Protein is depicted as a backbone C-trace. Helices are indicated. Atoms are represented in standard color scheme: carbon: grey, nitrogen: blue, oxygen: red, sulfur: yellow. Dotted lines indicate H-bonds. The figures have been generated by using WebLab Viewer.
(A) The 9-cis RA in the hsRXR
LBP. The protein is colored in light purple. The ligand is depicted in orange. Only a few side chains are labeled for clarity.
(B) Docking of the acidic JH I in the hvUSP LBP agonist model. The protein is colored in light blue. The ligand is colored in green.
(C) Docking of the ester JH III in the dmUSP LBP agonist model. The protein is colored in green. The ligand is colored in cyan. The dotted circle corresponds to the H-bond network region to which the ester group of JH binds.